Kontakt
Wie einkaufen
Versand
Kaufberater
In-vitro Drug Delivery System for Clarithromycin
Formulation with Pullulan acetate and Optimization by Response Surface Methodology
Englisch
82 b
Bis zu 30 Tage Rückgaberecht
Kunden kauften auch
/
Broschur
35.30
€
/
Hardcover
22.00
€
/
Hardcover
19.89
€
/
Broschur
26.00
€
/
Broschur
47.95
€
/
Hardcover
48.09
€
/
Hardcover
36.49
€
The aim of this investigation was to develop and optimize Claritromycin loaded with pullulan acetate for sustained release application by response surface methodology based on factorial design with reduced 2FI Model. Various parameters like RPM, Time, Drug (Clarithromycin) Concentration and Pullulan acetate concentration were optimized with respect to F5. It was found that RPM and Time were having more effect as compared to Clarithromycin and Pullulan acetate concentration for sustained release of the drug. The 3D response plot was drawn and optimum interactions were selected by feasibility and grid searches. The observed responses were coincided well with the predicted values by the experimental design. The optimized formulation F5 showed prolonged sustained release of Clarithromycin over 7 hours. The release profile of the drug loaded microsphere reveals that pH of the medium was influencing it at in vitro condition. In the optimized conditions, the sustained release can be reached up to 9 h. Therefore Pullulan acetate loaded with Clarithromycin is a useful polymerised materials for the development and formulation of pH sensitive drug.
Informationen zum Buch
Englisch
Kategorie
Verschenken Sie dieses Buch noch heute
Es ist ganz einfach
1 Legen Sie das Buch in Ihren Warenkorb und wählen Sie den Versand als Geschenk 2 Wir schicken Ihnen umgehend einen Gutschein 3 Das Buch wird an die Adresse des beschenkten Empfängers geliefertDas könnte Sie auch interessieren
/
Broschur
10.09
€
/
Hardcover
217.19
€
/
Broschur
14.30
€
/
Broschur
19.39
€
/
Broschur
12.60
€
/
Broschur
21.50
€
Hallo! Ich bin Libroamiko, dein Buchberater.
Wie kann ich dir helfen?