Targeted Protein Degradation Technologies

Targeted Protein Degradation Technologies provides a thorough overview of targeted protein degradation from the latest developments in the field to potential therapeutic applications. It begins with an introduction to the mechanisms of protein degradation, followed by a section covering both protease-mediate degradation and lysosome-mediate degradation. A range of cutting-edge technologies are covered, including PROTAC, AbTAC, molecular glues, hydrophobic tagging, LYTAC, GlueTAC and AUTAC. Degraders of specific proteins are then investigated, including signal transduction receptors, membrane proteins, and transcription factor degraders. The book closes with a section on the clinical applications of targeted protein degradation and a look at future perspectives. This book is a useful resource to those in the fields of molecular biology, cell biology and related areas working with protein degradation and the development of therapeutic technologies in this arena.

• Offers a foundational introduction to the mechanisms of protein degradation
• Features a range of targeted protein degradation technologies and covers the latest advances in each area
• Explores the clinical potential of protein degraders in drug discovery