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Regeneration of periodontal tissues so that their original form, architecture and function are restored has been an elusive but laudable goal. The major challenges in contemporary periodontal therapy are to re-establish soft tissue attachment to newly formed cementum on the root surface and to restore lost bone. This requires regeneration of gingival connective tissues destroyed by inflammation, formation of new cementum and restoration of bone loss, and, most importantly, new attachment of connective tissue fibers to previously diseased root surfaces.When considering periodontal regeneration, at least four criteria must be met15:1. A functional epithelial seal must be re-established at the most coronal portion of the tissues and be no more than 2 mm in length.2. New connective tissue fibers (Sharpey's fibers) must be inserted into previously exposed root surface.3. New acellular, extrinsic fiber cementum must be reformed on the previously exposed root surface.4. Alveolar bone height must be restored to within 2 mm of the cementoenamel junction.
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