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The COVID-19 pandemic is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrate persistent systemic symptoms, which are believed to have an autoimmune-related mechanism. This novel long-term effect of COVID-19 on recovered individuals was referred to as the "post-COVID19 syndrome’. It is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period. "The effects of COVID-19 and post-COVID19 syndrome on autoimmunity" fulfills the vital need in the medical community to help better understand the acute and chronic impact of the SARS-CoV-2. Describe the short and long impact of COVID-19 on autoimmunity Provides understanding to the acute and chronic impact of the SARS-CoV-2 Gives insight into the long-term effects of COVID 19 on recovered patients Provides conclusions on the novel term "chronic post-COVID19 syndrome", "post-acute COVID19 syndrome", or "long COVID-19"