DNA-Based Self-Assembly and Nanorobotics

We study the following fundamental questions in DNA-§based self-assembly and nanorobotics: How to control §errors in self-assembly? How to construct complex §nanoscale objects in simpler ways? How to transport §nanoscale objects in programmable manner? In our §quest to answer these questions, we present a §comprehensive theory of compact error-resilient §schemes for algorithmic self-assembly in two and §three dimensions, and discuss the limitations and §capabilities of redundancy based compact error §correction schemes. We present a time-dependent glue §model for reversible self-assembly model. We can §assemble thin rectangles of size k×N using O§(logN/loglogN) types of tiles in our model. We §present a framework for a discrete event simulator §for DNA-based nanorobotical systems. We design a §class of DNAzyme based nanodevices that are §autonomous, programmable, and require no protein §enzymes. In addition to these, we also attempt to §harness the mechanical energy of a polymerase 29 to §construct a polymerase based nanomotor that pushes a §cargo on a DNA track. We study the following fundamental questions in DNA-§based self-assembly and nanorobotics: How to control §errors in self-assembly? How to construct complex §nanoscale objects in simpler ways? How to transport §nanoscale objects in programmable manner? In our §quest to answer these questions, we present a §comprehensive theory of compact error-resilient §schemes for algorithmic self-assembly in two and §three dimensions, and discuss the limitations and §capabilities of redundancy based compact error §correction schemes. We present a time-dependent glue §model for reversible self-assembly model. We can §assemble thin rectangles of size k×N using O§(logN/loglogN) types of tiles in our model. We §present a framework for a discrete event simulator §for DNA-based nanorobotical systems. We design a §class of DNAzyme based nanodevices that are §autonomous, programmable, and require no protein §enzymes. In addition to these, we also attempt to §harness the mechanical energy of a polymerase 29 to §construct a polymerase based nanomotor that pushes a §cargo on a DNA track.