Cardiovascular Applications of Stem Cells

The book covers multifarious aspects of stem cell-based therapy for cardiovascular applications. In addition to stem cells from different sources for cell-based therapy, the book covers stem cell organoids and stem cell-derived exosomes, which are the advanced level development in regenerative medicine. The book encompasses advances in state-of-the-art infrastructure to improve the maturation aspects of pluripotent stem cells-derived cardiomyocytes using a novel scaffold-based cell culture system for cell delivery in experimental animal models and clinical settings. Besides the use of MSCs, the book includes chapters on the use of cardiac progenitor cells (CPCs), microtissue implantation, use of PSCs for valvulopathies, application of de-cellularized organ arrays as natural scaffolds for cardiac tissue engineering, use of epicardial stem cells, and skeletal myoblasts in cell-based therapy for myocardial regeneration. Besides the cell-based therapy approach, stem cell-derived exosomes, their characteristics, and engineering strategies to enhance their therapeutic potential via targeting and drug loading and use in disease models have also been discussed in the book. Additionally, stem cell therapy advances discuss the latest research on injectable hydrogels for cardiovascular regeneration and how hydrogel-based delivery protect the cells and their retention post engraftment in the heart, a problem, which significantly reduces the efficacy of cell-based therapy.